Table of Content: 1. Headache-Classification 2. The Epidemiology and Impact of Migrain 3. Progressive Headache: Epidemiology, Natural History, and Risk Factors 4. Comorbidity of Migrain 5. Pain Sensitivity: Intracranial and Extracranial Structures 6. Pathophysiology of Aura 7. Pathophysiology of Migraine 8. Allodynia and Sensitization in Migrain 9. Genetics of Migrain and Other Primar…